Repeated miscarriages or recurrent IVF failures may be due to immunological problems that lead to premature rejection of the embryo before pregnancy can be detected by even the most sensitive tests. A woman often produces perfectly viable embryos that are then lost through repeated "mini-abortions". This often occurs in women who have conditions such as endometriosis, a hypo-active thyroid, or in cases of "unexplained or idiopathic” infertility. Miscarriages that cannot be attributed to chromosomal defects, hormonal problems or abnormalities of the uterus are labeled "unexplained". It has been estimated that immune factors may be involved in more than 20% of couples with unexplained infertility. The ability of a woman to carry a pregnancy to term depends on a complex interaction of sophisticated immunological mechanisms developed to convert her uterus into an environment that avoids the rejection of the embryo, fetus and placenta. Sometimes this mechanism may be altered, and depending upon how and when this happens, the woman may experience recurrent miscarriages, infertility, or failure to conceive after IVF. The Assisted Reproduction Center specializes in treatment of these cases and through careful monitoring of patients and specialized treatments may increase the likelihood of achieving a pregnancy.
Indications for multiple failures
1) two miscarriages or two IVF failures after age 35 or three miscarriages or IVF failure before the age 35;
2) idiopathic (unknown causes) infertility;
3) previous immune problems (ANA positive, rheumatoid arthritis, and/or lupus);
4) previous pregnancies that have shown retarded fetal growth;
5) one living child and repeat miscarriages while attempting to have a second child.
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