Donation - Oocytes donation

Oocytes donation

A female at birth has many hundreds of thousands of immature oocytes in her ovaries. During her fertile years she usually ovulates one mature ”egg” every month, consequently producing up to 500 before she reaches the menopause. 
Very few  of these “eggs” are used to realize her family. Some women choose to donate excess eggs to others, allowing also them to fulfill their dream of a family.
Once all the necessary clinical and diagnostics tests are carried out and the suitability of the donor is ascertained, the menstrual cycles of the donor and recipient are synchronized using fertility drugs. 
Women in menopause are placed on a hormone replacement type therapy. In time for the oocyte retrieval of the donor, the recipient couple travel to the IVF clinic to complete the administrative forms and produce the husbands sperm. 
Embryos are produced in vitro and  a maximum of three transferred into the uterus of the prospective mother. Following transfer, the couple return to their home country . After 14 days a pregnancy test may be carried out.
Patients who request oocyte donation are typically in their 40’s, often producing poor oocytes that may lead to a high percentage of chromosomally abnormal embryos in vitro. They are:
 
-Women in menopause
-Women who have had their ovaries surgically removed
-Couples at risk of transmitting genetic disease
-Couples with repeated IVF failure
-Women with ovarian function that for medical reasons cannot use their own oocytes.
 
For a variety of social reasons your biological age has not coincided with your desire for motherhood and now nature needs a helping hand.
Below we outline the principles of gamete donation and the pathway leading to this technique.
Compared to homologous (own oocytes) fertilization, heterologous IVF/ICSI is extremely efficient with pregnancy rates reaching 70% per embryo transfer. This is mainly due to the biological age of the donors. The accumulative rate for three cycles may reach 95%, miscarriage is about 13% and extrauterine pregnancies 1.3%.

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